December 1, 2022 4:12 am

Publications

Madeline F. Malfara, Lee J. Silverberg, John DiMaio, Anthony F. Lagalante, Mark A. Olsen, Ekaterina Madison, Megan L. Povelones. 2,3-Diphenyl-2,3-dihydro-4H-1,3-thiaza-4-one heterocycles inhibit growth and block completion of cytokinesis in kinetoplastid parasites, Molecular and Biochemical Parasitology, 2021, 111396,
ISSN 0166-6851, https://doi.org/10.1016/j.molbiopara.2021.111396.

Budzak, James, Louise E. Kerry, Aris Aristodemou, Belinda S. Hall, Kathrin Witmer, Manish Kushwaha, Carys Davies, Megan L. Povelones, Jacquelyn R. McDonald, Aakash Sur, Peter J. Myler, Gloria Rudenko. “Dynamic Colocalization of 2 Simultaneously Active VSG Expression Sites within a Single Expression-Site Body in Trypanosoma brucei.” Proceedings of the National Academy of Sciences 116, no. 33 (August 13, 2019): 16561–70. https://doi.org/10.1073/pnas.1905552116.

Filosa, John N., Corbett T. Berry, Gordon Ruthel, Stephen M. Beverley, Wesley C. Warren, Chad Tomlinson, Peter J. Myler, Elizabeth A. Dudkin, Megan L. Povelones, and Michael Povelones. “Dramatic Changes in Gene Expression in Different Forms of Crithidia fasciculata Reveal Potential Mechanisms for Insect-Specific Adhesion in Kinetoplastid Parasites.” PLOS Neglected Tropical Diseases 13, no. 7 (July 29, 2019): e0007570. https://doi.org/10.1371/journal.pntd.0007570.

DiMaio, John, Gordon Ruthel, Joshua J. Cannon, Madeline F. Malfara, and Megan L. Povelones. “The Single Mitochondrion of the Kinetoplastid Parasite Crithidia fasciculata Is a Dynamic Network.” PLOS ONE 13, no. 12 (December 28, 2018): e0202711. https://doi.org/10.1371/journal.pone.0202711.

Maree, Johannes Petrus, Megan Lindsay Povelones, David Johannes Clark, Gloria Rudenko, and Hugh-George Patterton. “Well-Positioned Nucleosomes Punctuate Polycistronic Pol II Transcription Units and Flank Silent VSG Gene Arrays in Trypanosoma brucei.” Epigenetics & Chromatin 10, no. 1 (March 20, 2017): 14. https://doi.org/10.1186/s13072-017-0121-9.

Povelones, Megan L. “Beyond Replication: Division and Segregation of Mitochondrial DNA in Kinetoplastids.” Molecular and Biochemical Parasitology 196, no. 1 (August 1, 2014): 53–60. https://doi.org/10.1016/j.molbiopara.2014.03.008.

Povelones, Megan L., Calvin Tiengwe, Eva Gluenz, Keith Gull, Paul T. Englund, and Robert E. Jensen. “Mitochondrial Shape and Function in Trypanosomes Requires the Outer Membrane Protein, TbLOK1.” Molecular Microbiology 87, no. 4 (2013): 713–29. https://doi.org/10.1111/mmi.12089.

Povelones, Megan L., Eva Gluenz, Marcin Dembek, Keith Gull, and Gloria Rudenko. “Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei.” PLOS Pathogens 8, no. 11 (November 1, 2012): e1003010. https://doi.org/10.1371/journal.ppat.1003010.

Clayton, April M., Jennifer L. Guler, Megan L. Povelones, Eva Gluenz, Keith Gull, Terry K. Smith, Robert E. Jensen, and Paul T. Englund. “Depletion of Mitochondrial Acyl Carrier Protein in Bloodstream-Form Trypanosoma brucei Causes a Kinetoplast Segregation Defect.” Eukaryotic Cell 10, no. 3 (March 2011): 286–92. https://doi.org/10.1128/EC.00290-10.

Gluenz, E., M. L. Povelones, P. T. Englund, and K. Gull. “The Kinetoplast Duplication Cycle in Trypanosoma brucei Is Orchestrated by Cytoskeleton-Mediated Cell Morphogenesis.” Molecular and Cellular Biology 31, no. 5 (March 1, 2011): 1012–21. https://doi.org/10.1128/MCB.01176-10.

Liu, Beiyu, Jianyang Wang, Nurit Yaffe, Megan E. Lindsay, Zhixing Zhao, Aviad Zick, Joseph Shlomai, and Paul T. Englund. “Trypanosomes Have Six Mitochondrial DNA Helicases with One Controlling Kinetoplast Maxicircle Replication.” Molecular Cell 35, no. 4 (August 28, 2009): 490–501. https://doi.org/10.1016/j.molcel.2009.07.004.

Lindsay, Megan E., Eva Gluenz, Keith Gull, and Paul T. Englund. “A New Function of Trypanosoma brucei Mitochondrial Topoisomerase II Is to Maintain Kinetoplast DNA Network Topology.” Molecular Microbiology 70, no. 6 (2008): 1465–76. https://doi.org/10.1111/j.1365-2958.2008.06493.x.

Li, Ziyin, Megan E. Lindsay, Shawn A. Motyka, Paul T. Englund, and Ching C. Wang. “Identification of a Bacterial-Like HslVU Protease in the Mitochondria of Trypanosoma brucei and Its Role in Mitochondrial DNA Replication.” PLOS Pathogens 4, no. 4 (April 18, 2008): e1000048. https://doi.org/10.1371/journal.ppat.1000048.

Zhao, Zhixing, Megan E. Lindsay, Arnab Roy Chowdhury, Derrick R. Robinson, and Paul T. Englund. “P166, a Link between the Trypanosome Mitochondrial DNA and Flagellum, Mediates Genome Segregation.” The EMBO Journal 27, no. 1 (January 9, 2008): 143–54. https://doi.org/10.1038/sj.emboj.7601956.

Englund, P.T., E.E.C. Agbo, M.E. Lindsay, B. Liu, Y. Liu, S.A. Motyka, G. Yildirir, and Z. Zhao. “RNAi Libraries and Kinetoplast DNA.” Biochemical Society Transactions 33, no. 6 (October 26, 2005): 1409–12. https://doi.org/10.1042/BST0331409.